going in a straight line, in theory, all wheels should be rotating at the same speed. the diffs then are not spinning internally, only as a whole. therefore they are generating less heat, wearing out slower, and spreading the power evenly between the wheels.
it wouldn't be much, possibly negligible really, but to me it's not really a hassle to avoid; don't rotate in the spare/ do rotate from new.
The other thing that comes to mind is wet weather driving with one 'grippy' tyre and 3 with less traction. Again, theoretically.
If you are playing the devil, do I get to be god? :angel:
possibly more theory than reality, but it's up to you.

