Yes
Quote from NYC government:
"Tolerance is how your body adapts to regular use of a drug over time. As you develop tolerance to a drug, you will usually need to use more of it to feel the effect you want. If you have no or low tolerance to a drug, using even a small amount can increase your risk of overdose."
You may just need to do more, in order to achieve serene levels of stupor, Grasshopper....
Make sure the bar is well stocked first.

