The answer is - it all depends! On the slope, the wind, and the terrain beyond the end of the airstrip.
As a general rule, takeoff should always be into wind unless the wind is very light, or the available takeoff run adequate - the required length can be calculated knowing the tailwind. Generally avoid taking off downwind as it increases distance required and groundspeed at liftoff.
But.....takeoff uphill should always be avoided unless there is no other option and there is a headwind that is a good proportion of the takeoff speed. Or if the slope is very slight.
John
JDNSW
1986 110 County 3.9 diesel
1970 2a 109 2.25 petrol
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