The timber airplanes were also monocoques really - one might say wooden space frames I guess.
The DC4 followed the reliable DC3 - the DC4's tails would drop off. The Electra plain that our Air Forces still use for radar tracking / defence (being replaced though) - also their tails would fall off. My Mum flew DC4's to Vancouver, from Melbourne. It took her a week. My dad flew Typhoons and Spitfires in WWII.
As far as alloy goes - it really does fatigue. Just ask a racing yachtsman, who uses an alloy mast. These fatigue. An example is a close friend of mine - Hugo Ottaway from Insail in Melbourne. He races a J24, an international small racing keelboat. He has been to many world championships, representing Australia. He replaces his costly alloy mast regularly - because the mast moves or flexes, in order to control the sail shape. And when it moves, it fatigues, it hardens. This results in it loosing its elasticity - and its "spring". This slows the boat down. So he replaces his masts, because its necessary. This all happens because aluminium really does work harden.
Meanwhile steel is much less subject to work hardening. Caste iron itself suffers this issue much less than steel. Perhaps why our Lr's still use a high spec chrystalline or compacted / vermicular graphite iron for their V6 engine blocks. While lesser loaded motors use aluminium. I am guessing iron is better than alloy in a high load diesel engine. I think due to good design.
I don't know of any alloy chassis based vehicle.
For towing, I'd rather the vehicle weighed 150kg more, and had a chassis. And I'd be worried about it having an alloy chassis. Without towing or doing off road stuff, an alloy monocoque and also composites, promise much more efficiency. The new RRS is heaps better for most people. 90K for the base model seems great value too IMO. But I suspect for my usage, its not as good.

