Other than fixing my kids' bikes I have had bugger all to do with push bikes since I was a teenager. I have spec'd up plenty of motor trucks though. Total Horsepower Requirement is the sum of Rolling Resistance Horsepower, Grade Resistance Horsepower, Air Resistance Horsepower. I calculated that at 10,000 lbs GCM, first class concrete highway, 64 sq. ft. frontal area (8' x 8' van), 1% Grade, to be 111 horsepower plus accessory losses (fan, pumps, alternator, compressors).
Having established your horsepower requirement, the next step is to create a gear split chart and compare it to the manufacturers literature to see if the engine is producing sufficient power at the desired road speed. You may need to change your final drive ratio or gearbox to achieve this.
The heavy transport industry generally accepts that aerodynamic aids have little effect below highway speeds.
Horsepower requires fuel. If you are not fed then you won't work well either.

