There are realy 2 key differences:
D2x is a full pro body and is heavier and larger to carry
D300 is a much newer camera and has far better ISO performance and imaging ability.
I know what it is like lugging the D3s around and I have my D200 as a backup. The thing that makes me reach for the D3s is the fact is is so much more advanced at image capture over the D200. But the weight is a killer if you have to carry it for several hours.
I'd go the D300 and see if you can get a D300s.
MY15 Discovery 4 SE SDV6
Past: 97 D1 Tdi, 03 D2a Td5, 08 Kimberley Kamper, 08 Defender 110 TDCi, 99 Defender 110 300Tdi[/SIZE]
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