download hirens boot disk

whilst it downloads

uninstall all anti virus programs except the one you trust the most.

uninstall malwarebytes, adaware, ccleaner, spybot and all the other anti malware tools you have collected.

mount hirens or burn it to disc

now turn off your antivirus program until next reboot

dont boot from hirens just run the hbcd menu cmd off the cd under windows

under cleaners

atf cleaner select all but then untick cookies

ccleaner run the cleaner and then the registry fixer

then check the startup items in the tools menu

clary reg cleaner

under optimsers

if using xp use the nt registry optimiser

if not using an SSD use defragler to do a file defragment (analyse then filelist then tick all files)

DO NOT run a defragment program on an SSD as it tends to kill them.

under anti virus

run combofix

reboot if combofix doesn't already cause one

do a full anti virus scan with your av of choice

if you want the best performance from your machine and aren't worried about pretty then alter the performance settings in the control panel to "best performance" instead of "let windows control" performance. (Control Panel -> System -> Advanced -> Performance)

usually gets a machine up to speed again

hope it helps.