Smaller block size doesn't necessarily equal better performance. It all depends on what types of files you will be storing on there - smaller files = smaller block size. Larger files = larger block size.
If you have larger files then a larger block size will mean less reads from the disk to pick up the entire file.
If you have smaller files then a block size larger than the file will mean the disk has to read a heap of empty space before delivering the file.
.. and yes you can backup your RAID-0 to a single disk, in fact you can back it up to anything it won't matter.





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