The "special" substances are a range of products added by refineries to improve lubricity without harming cetane rating.
The difference is the additives the refineries add have been subject to a battery of tests to ensure suitability. There is no guarantee that your homebrew 2-stroke (or other additives) won't do more harm than good.
Bush65 commented in another thread, that many injector pumps (e.g. ISUZU) are lubricated by engine oil rather than fuel. So adding a lubricant to the fuel won't make a difference to IP longevity.
The main claim of the proponents of 2-stroke, is that the engine "sounds smoother". How is better lubrication of the pump(s) and injectors supposted to be "heard"??? If the engine runs smoother with 2-stroke added, it sounds more like a moderation of the combustion process, which may or may not be a good thing.
Case in point, a friend converted his isuzu diesel to run on WVO. He didn't realise that he had low compression on one cylinder. The result, his engine idles smoothly (all 4 cylinders) on WVO, but roughly (3 cylinders) on Diesel. You could use that to say that it is much better for the engine to run it on WVO, but we know that is not necessarily the case, There are lots of potential downfalls of using straight WVO.



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